Job Ref: 22580
Talent Area: Research - Clinical
Houston Methodist Research Institute
Houston, TX 77030
Area/Department: BioMarker Research Cancer
Employment Type: Regular
Job Type: Full-Time
Organization: Houston Methodist
M - F
Houston Methodist Research Institute was formed in 2004 to rapidly and efficiently translate discoveries made in the laboratory and the clinic into new diagnostics, therapies and treatments. The research institute was created to provide the infrastructure and support for these endeavors, and to house the technology and resources needed to make innovative breakthroughs in important areas of human disease. A 440,000 square foot building dedicated to research, the research institute houses over 1,150 staff members, 270 principal investigators and has more than 600 ongoing clinical trials.
The laboratory investigates the biology, properties and clinical utilities of Circulating Tumor Cells (CTCs) – “seeds” of fatal metastatic disease which is the major cause of cancer patients’ mortality. CTCs are proving to be viable diagnostic tools for noninvasive real-time assessment of cancer progression (“liquid biopsy”). Evaluation of CTCs may enable a more sensitive monitoring of treatment efficacy, thus guiding drug selection in adjuvant settings where no such tools exist today. However, current technologies prevent researchers from identifying the majority of the CTCs from cancer patients that spread (metastasize) within the body, notably to brain. Brain metastasis represents an urgent clinical problem which is increasing in frequency with dismal patient survival rates.
Postdoctoral position are immediately available to investigate the mechanisms of breast cancer brain metastasis, notably the biology and therapeutic utilities of Circulating Tumor Cells (CTCs) - the “seeds “of metastatic disease -. This position is of high relevance and the postdoctoral fellow will be responsible of implementing pioneering projects in the cell and molecular biology of metastatic specificity to brain; involving the use of human cell lines, animal models, and clinical samples reflective of disease status. Ph.D. is required. Candidates must possess:
Dr. Marchetti and team are working to develop a vigorous biomarker program with Houston Methodist Hospital faculty across numerous disciplines with a primary focus on breast cancer brain metastasis. One of his main priorities is to better understand why breast cancer reoccurs and how to decipher the molecular heterogeneity of CTC subset phenotypes responsible for seeding/reseeding metastases and leading to patients’ death.
Dr. Marchetti is an internationally recognized expert and authority in the field of circulating tumor cells (CTCs) CTCs can be clinically useful tools to combat cancer metastasis for improved patient outcome, prime examples of precision medicine. With keen insights into the biology of brain metastasis, he pioneered models discovering molecular determinants underlying brain metastasis and biomarker properties of brain-homing CTCs.
DUTIES AND RESPONSIBILITIES
M.D. or Ph.D required
Experience requirements will vary depending on the field of research.
Postdoctoral Fellow 0– no Postdoc experience required
Postdoctoral Fellow 1– one year of Postdoc experience
Postdoctoral Fellow 2 – two years of experience
Postdoctoral Fellow 3 – three years of postdoc experience
Postdoctoral Fellow 4 – four years of postdoc experience
CERTIFICATES, LICENSES AND REGISTRATIONS REQUIRED
SPECIAL KNOWLEDGE, SKILLS AND ABILITIES REQUIRED
Experience in biomedical research required.
Research laboratory environment.
Once you have successfully completed the application, please be prepared to provide three letters of reference during the interview process.
Houston Methodist is an Equal Opportunity Employer.
Equal employment opportunity is a sound and just concept to which Houston Methodist is firmly bound. Houston Methodist will not engage in discrimination against or harassment of any person employed or seeking employment with Houston Methodist on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, status as a protected veteran or other characteristics protected by law.
VEVRAA Federal Contractor – priority referral Protected Veterans requested.