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Postdoctoral Fellow

Job Ref: 22580

Talent Area: Research - Clinical

Houston Methodist Research Institute
Houston, TX 77030

Area/Department: BioMarker Research Cancer

Employment Type: Regular

Job Type: Full-Time

Organization: Houston Methodist

Work Shift


Work Week

M - F

Company Profile

Houston Methodist Research Institute was formed in 2004 to rapidly and efficiently translate discoveries made in the laboratory and the clinic into new diagnostics, therapies and treatments.  The research institute was created to provide the infrastructure and support for these endeavors, and to house the technology and resources needed to make innovative breakthroughs in important areas of human disease.  A 440,000 square foot building dedicated to research, the research institute houses over 1,150 staff members, 270 principal investigators and has more than 600 ongoing clinical trials.

Job Summary

The laboratory investigates the biology, properties and clinical utilities of Circulating Tumor Cells (CTCs) – “seeds” of fatal metastatic disease which is the major cause of cancer patients’ mortality. CTCs are proving to be viable diagnostic tools for noninvasive real-time assessment of cancer progression (“liquid biopsy”).  Evaluation of CTCs may enable a more sensitive monitoring of treatment efficacy, thus guiding drug selection in adjuvant settings where no such tools exist today.  However, current technologies prevent researchers from identifying the majority of the CTCs from cancer patients that spread (metastasize) within the body, notably to brain.  Brain metastasis represents an urgent clinical problem which is increasing in frequency with dismal patient survival rates.

Postdoctoral position are immediately available to investigate the mechanisms of breast cancer brain metastasis, notably the biology and therapeutic utilities of Circulating Tumor Cells (CTCs) - the “seeds “of metastatic disease -.  This position is of high relevance and the postdoctoral fellow will be responsible of implementing pioneering projects in the cell and molecular biology of metastatic specificity to brain;   involving the use of human cell lines, animal models, and clinical samples reflective of disease status.  Ph.D. is required.   Candidates must possess:

  •  A strong laboratory experience with a profound knowledge and experience with cutting-edge molecular biology technologies, experimental animal proficiency (eg, mammary fat pad/subcutaneous-IV/intracardiac and/or intracarotid  tumor cell injections in nude/SCID-hu mice), biomaging, and strong abilities to work independently and with self-initiative. 
  •  Abilities to vigorously pursue scientific projects, both conceptually and experimentally, with pro-active thinking and action;
  •  An inner motivation to succeed in a highly focused scientific environment;
  •  Highest work ethic and scientific integrity. 

Dr. Marchetti and team are working to develop a vigorous biomarker program with Houston Methodist Hospital faculty across numerous disciplines with a primary focus on breast cancer brain metastasis. One of his main priorities is to better understand why breast cancer reoccurs and how to decipher the molecular heterogeneity of CTC subset phenotypes responsible for seeding/reseeding metastases and leading to patients’ death.

Dr. Marchetti is an internationally recognized expert and authority in the field of circulating tumor cells (CTCs) CTCs can be clinically useful tools to combat cancer metastasis for improved patient outcome, prime examples of precision medicine. With keen insights into the biology of brain metastasis, he pioneered models discovering molecular determinants underlying brain metastasis and biomarker properties of brain-homing CTCs.


  • Develops research methods and performs research activities.  (EF)
  • Documents research results and writes reports of results for presentation and/or publication in professional journals and other publications.  (EF)
  • Assists in maintaining the functionality and operations of the Principal Investigator’s laboratory.  (EF)
  • Demonstrates the components of the I CARE values.  (EF)
  • Follows all safety rules while on the job.  Reports accidents promptly and corrects minor safety hazards.  Communicates with peers and management regarding any hazards identified in the workplace.  (EF)
  • Performs other duties as assigned by the Principal Investigator.


M.D. or Ph.D required


Experience requirements will vary depending on the field of research.

Postdoctoral Fellow 0– no Postdoc experience required

Postdoctoral Fellow 1– one year of Postdoc experience

Postdoctoral Fellow 2 – two years of experience

Postdoctoral Fellow 3 – three years of postdoc experience

Postdoctoral Fellow 4 – four years of postdoc experience


Not applicable


Experience in biomedical research required.


Research laboratory environment.


Once you have successfully completed the application and assessment, please be prepared to provide three letters of reference during the interview process.

Equal Employment Opportunity

Houston Methodist is an Equal Opportunity Employer.

Equal employment opportunity is a sound and just concept to which Houston Methodist is firmly bound. Houston Methodist will not engage in discrimination against or harassment of any person employed or seeking employment with Houston Methodist on the basis of  race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, status as a protected veteran or other characteristics protected by law.

VEVRAA Federal Contractor – priority referral Protected Veterans requested.