Job Ref: 27199
Talent Area: Research - Technical
Houston Methodist Research Institute
Houston, TX 77030
Employment Type: Regular
Job Type: Full-Time
Organization: Houston Methodist
Work Shift: DAY
Work Week: M - F
Houston Methodist Research Institute was formed in 2004 to rapidly and efficiently translate discoveries made in the laboratory and the clinic into new diagnostics, therapies and treatments. The research institute was created to provide the infrastructure and support for these endeavors, and to house the technology and resources needed to make innovative breakthroughs in important areas of human disease. A 540,000 square foot building dedicated to research, the research institute houses over 1,500 staff and trainees, 277 principal investigators and has more than 840 ongoing clinical trials.
Post-doctoral fellowship to characterize the functional impact of TWIST1 dimerization motifs on malignant phenotypes of glioma stem cells
A post-doctoral fellow is sought to join the Rostomily lab at the Houston Methodist Research Institute. The fellow will participate in the study of TWIST1 dimerization motifs and the molecular mechanisms by which they influence glioma stem cell (GSC) phenotypes. TWIST1, a bHLH transcription factor (TF), is a central regulator of epithelial mesenchymal transition (EMT) in a wide variety of cancers. In glioma we have shown that TWIST1 promotes invasion, tumorigenicity and stem cell properties. TWIST1 transcriptional activity requires the formation of homo- or heterodimers. The current project seeks to determine how specific TWIST1 dimer motifs influence malignant properties of GSCs, identify mechanisms which govern the formation of specific dimer motifs and elucidate dimer motif-specific downstream molecular mechanisms which regulate GSC malignant properties. Given the difficulties in targeting TFs directly, these studies are expected to provide new insights into alternative therapeutic strategies to indirectly target TWIST1 function through TWIST1 regulated proteins. The candidate must have a strong background in molecular and cellular cancer biology and expertise in a variety of the approaches utilized for this project including cloning and characterization of tethered protein-protein expression constructs, RNAseq, CHIPseq, promoter reporter assays, proteomics, CRIPSR or shRNA mediated loss of function, GSC culture and generation and immuno-histologic characterization of xenograft tumors. Experience with bioinformatics tools for data analysis is a plus.
Performs basic research duties under the supervision/direction of a Physician (Principal Investigator).
System and department specific ICARE values
INTEGRITY: We are honest and ethical in all we say and do.
COMPASSION: We embrace the whole person including emotional, ethical, physical, and spiritual needs.
ACCOUNTABILITY: We hold ourselves accountable for all our actions.
RESPECT: We treat every individual as a person of worth, dignity, and value.
EXCELLENCE: We strive to be the best at what we do and a model for others to emulate.
Duties and Responsibilities are cross-referenced to the hospital’s Pillars of Excellence and will be transferred to the Performance Evaluation.
Assists in maintaining the functionality and operations of the Principal Investigator’s laboratory
Follows all safety rules while on the job.Reports accidents promptly and corrects minor safety hazards.Communicates with peers and management regarding any hazards identified in the workplace.
Develops research methods and performs research activities.
Documents research results and writes reports of results for presentation and/or publication in professional journals and other publications.
This position description is not intended to be all inclusive, and the employee will also perform other reasonably related business duties as assigned by the immediate supervisor and other management as required. The Houston Methodist Hospital reserves the right to revise or change job duties and responsibilities as the need arises.
Ph.D. or M.D. required
Experience requirements will vary depending on the field of research.
Postdoctoral Fellow 0– no Postdoc experience required
Postdoctoral Fellow 1– one year of Postdoc experience
Postdoctoral Fellow 2 – two years of experience
Postdoctoral Fellow 3 – three years of postdoc experience
Postdoctoral Fellow 4 – four years of postdoc experience
CERTIFICATES, LICENSES AND REGISTRATIONS REQUIRED
SPECIAL KNOWLEDGE, SKILLS AND ABILITIES REQUIRED
Experience in biomedical research required.
Research laboratory environment.
Research laboratory environment
Houston Methodist is an Equal Opportunity Employer.
Equal employment opportunity is a sound and just concept to which Houston Methodist is firmly bound. Houston Methodist will not engage in discrimination against or harassment of any person employed or seeking employment with Houston Methodist on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, status as a protected veteran or other characteristics protected by law.
VEVRAA Federal Contractor – priority referral Protected Veterans requested.